Human hepatoma HepG2 cells incubated with normal glucose (5.5 mM, NG model), high glucose (33 mM, HG model), or high glucose (33 mM) plus high insulin (10−7 M, HGI model) concentrations were administered with TV LH-1 ePSP (50, 100, and 1000 μg/ml) for 24 hr. This evidence concerns the gene PLOD1 and hepatocellular carcinoma.