SBMT of TPA-containing human samples revealed differences in the geographical distribution of syphilis-causing strains [19], showed changing temporal patterns in the same geographical area [20], showed an association between certain TPA genotypes with mutations causing macrolide resistance [19–21], and showed associations between certain TPA genotypes and groups of patients including men having sex with men (MSM) [20]. The gene discussed is PLAT; the disease is syphilis.