The results elucidated that Secreted Frizzled-Related Protein 1 (SFRP1) and Secreted Frizzled-Related Protein 2 (SFRP2) methylation possess the highest accuracy for detection of not only CRC (DOR: 31.67; 95%CI, 12.31–81.49 and DOR: 35.36; 95%CI, 18.71–66.84, respectively) but also the early stages of cancer, TA (DOR: 19.72; 95%CI, 6.68–58.25 and DOR: 13.20; 95%CI, 6.01–28.00, respectively) as illustrated in Fig 2. Here, SFRP2 is linked to cancer.