As patients with NAFLD are known to have altered levels of miR-122; and as most of NAFLD patients have some degree of insulin resistance, our results highlight the role of miR-122 in insulin sensitivity suggests that miR-122 mimics could play a useful role in reversing liver inflammation, steatofibrosis and insulin resistant seen in these patients. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.