In our miR-122 inhibited organoids, TIMP2 and TIMP3 expression still remains high at day 11 post-infection while MMP8 decreases more than 2- fold at day 11 vs day 4 post-infection though we see a slight increase in the levels of MMP1 and MMP9 at day 11 compared with day 4. The gene discussed is MMP8; the disease is infection.