MiR-122 inhibition also leads to an increase in expression of GLUT4 and a consequent increase in transport of glucose into the hepatocytes and this leads to desensitizing insulin receptor as it is evident by decrease in expression of IRS1 and several other molecules (SREBP1, FAS, FoxA2) under insulin signaling in one hand and increase in release of inflammatory cytokines (IL6, TNFα) and chemokines (CCL2, CCL3, CXCR4) from Kupffer cells due to hepatocyte death as was seen after 11 days post-infection. The gene discussed is TNF; the disease is infection.