Currently, many studies have sought to determine the best marker for differentiating between mesothelial cells and adenocarcinoma over the broad spectrum.[2] ICC using LBC has been widely used in vaginal cytology with Ki-67 and p16,[4,5] and later adopted in urine cytology for aiding in identification of high-grade urothelial carcinoma.[6] However, no supportive data on dual staining using other markers has been documented. The gene discussed is MKI67; the disease is urothelial carcinoma.