BAX and cancer: The BAX gene is the apoptotic gene directly regulated by P53, located on the human chromosome 19q13.3, encoding 6 exons and 1 promoter.[3] Bax promotes programmed cell death by the intrinsic pathway with a series of changes including conformational switching, trafficking, and aggregation status changes.[4] The association between BAX gene polymorphisms and cancer is related not only to the formation of cancer, but also to the prognosis of cancer.