BAX and cancer: In view of the important role of BAX gene in the formation and development of malignant tumor, Bax protein agonist is a very promising drug, warding off drug resistance, selectively inducing cancer cell apoptosis, and low toxicity in normal cells.[4,35] Our study suggests that the BAX rs4645878 gene polymorphism is associated with adverse outcomes, so patients with this gene polymorphism may be an appropriate group for these drugs.