EMT has been shown to occur in wound healing, organ fibrosis, and the development of cancer.[8] Ma et al[9] found that the EMT phenomenon existed in keloid tissue; they demonstrated that a hypoxia/hypoxia-inducible factor-1α (HIF-1α) rich microenvironment favored the transformation of keloid-derived keratinocytes into fibroblast-like cells through the EMT phenomenon, thus supporting the invasive growth of a keloid. The gene discussed is HIF1A; the disease is keloid.