DDIT3 and pseudoachondroplasia: These results are in contrast to the pro-apoptotic role reported for CHOP in a mouse model of Pseudoachondroplasia caused by expression of misfolded COMP in proliferating and hypertrophic chondrocytes, where deleting CHOP reduced apoptosis but exacerbated growth plate chondrocyte disorganisation (Posey et al., 2012; Piróg et al., 2014).