SOX9 is a potent transcription factor with critical roles in cell fate determination, not only in chondrocytes but also in many different cell types, notably stem cells (dermal papilla, gonads, intestinal and neural, etc.)(Posey et al., 2014; Pritchett et al., 2011) and is activated in other common and acquired diseases such as cancer and fibrosis (Pritchett et al., 2011; Athwal et al., 2017). This evidence concerns the gene SOX9 and cancer.