Although not demonstrated, that report suggests a mechanism for the abnormal osteoblast differentiation in osteogenesis imperfecta, given the link between eIF2α phosphorylation and preferential translation of transcripts encoding factors such as ATF4, a key regulator of osteoblast differentiation (reviewed in [Greenblatt et al., 2013]), and CHOP (Shirakawa et al., 2006), the ISR emerges as a likely effector of the abnormal osteoblast differentiation in osteogenesis imperfecta. This evidence concerns the gene ATF4 and osteogenesis imperfecta.