DNMT3B and pachyonychia congenita: The remaining four genes VAV2 (VAV guanine nucleotide exchange factor 2), ASNS (asparagine synthesis), DNMT3B (DNA methyltransferase 3 beta), and AURKA (Aurora kinase A) not only all promote PC pathogenesis but also play a role in the development of CRPC (Gravina et al., 2011; Magani et al., 2017; Mosquera et al., 2013; Sircar et al., 2012).