Among these 15 component genes include 5 candidate oncogenic genes and 6 novel PC genes; within these 11 novel genes affecting PC recurrence, 6 genes (SLCO2A1, SUPV3L1, TATDN2, MGAT4B, SLC25A33, and OIP5) individually predict PC recurrence after adjusting for the above clinical factors. This evidence concerns the gene SLCO2A1 and pachyonychia congenita.