The results of the present study also demonstrate that PBM treatment using red light (660 nm) induced a reduction in inflammatory infiltrate, myonecrosis, the number of CD68+ (M1) macrophages and the mRNA expression of TNF‐α after 2 days and promoted an increase in the number of immature muscle fibres and CD163+ (M2) macrophages after 7 days. This evidence concerns the gene TNF and gas gangrene.