A previous study found that p53 signalling pathway was found to be dysregulated in 85.3% of glioma patients according to the TCGA (The Cancer Genome Atlas) data.14 Herein, we analysed signalling pathways closely related to glioma using Gene Set Enrichment Analysis (GSEA) to confirm the aberrant condition of p53 pathway. The gene discussed is TP53; the disease is glioma.