SERPINE1 and colorectal cancer: For instance, SERPINE1 was found to be high‐expressed in colorectal cancer and related to tumour invasiveness and aggressiveness.15 Overexpression of SERPINE1 has also been found in many other cancers including melanoma,16 oesophageal cancer17 and bladder cancer.18 It can be seen as a poor prognosis biomarker.