For instance, up‐regulation of miR‐1275 regulated IGF2BPs to hinder tumour growth in hepatocellular carcinoma.24 It was reported that miR‐1275 exhibited its tumour suppressive role on nasopharyngeal carcinoma cells by down‐regulating oncogenic HOXB5, whose expression was negatively related to miR‐1275.25 In our study, we found that miR‐1275 was lowly expressed in glioma and its up‐regulation could suppress glioma cell function including proliferation, migration and invasion, as well as induce apoptosis. The gene discussed is HOXB5; the disease is hepatocellular carcinoma.