Clinically, SERPINE1 and its family member urokinase‐type plasminogen activator (uPA) both have been considered as important prognostic markers for various cancers, including breast cancer26 and papillary thyroid cancer.27 Our study further confirmed that it worked as a tumour promotor in glioma. This evidence concerns the gene SERPINE1 and thyroid gland papillary carcinoma.