SQSTM1 and myocardial infarction: This experimental study showed that pretreatment of type-II diabetic rats with vildagliptin significantly restored the positive effects of IPostC on cardioprotection, autophagic flux and mitochondrial function following reperfusion injury, characterized by improved myocardial infarction, decreased autophagic markers LC3B-II and p62, reduced mitochondrial ROS generation, decreased mitochondrial membrane depolarization and increased mitochondrial number and density.