Since GOF mutations in RHBDF2 cause skin hyperkeratosis and hyperplasia (Blaydon et al., 2012; Saarinen et al., 2012; Mokoena et al., 2018), Maruthappu et al. (2017) examined whether loss of RHBDF2 has any effect on skin thickness. The gene discussed is RHBDF2; the disease is neoplasm.