To demonstrate the powerful effect of Nf2 deficiency in inducing MM, Nf2-deficient mice were crossed with either Ink4a/Arf-deficient or p53-deficient mice, and in the absence of any exposure to asbestos, a high incidence of short median survival of invasive pleural mesothelioma developed (Altomare et al., 2005; Jongsma et al., 2008). Here, CDKN2A is linked to pleural mesothelioma.