Aside from extracellular ligands, excess of intracellular free fatty acids resulting from high fat diet increases cellular diacylglycerol to promote atypical CARMA3/CARD10–BCL10-dependent, but MALT1-independent NF-κB activation in hepatocytes and thereby BCL10 deficiency contributes to insulin resistance (45). Here, CARD10 is linked to Insulin resistance.