Aside from extracellular ligands, excess of intracellular free fatty acids resulting from high fat diet increases cellular diacylglycerol to promote atypical CARMA3/CARD10–BCL10-dependent, but MALT1-independent NF-κB activation in hepatocytes and thereby BCL10 deficiency contributes to insulin resistance (45). This evidence concerns the gene BCL10 and Insulin resistance.