We recently demonstrated that TMA, like lumacaftor, stabilizes the first membrane-spanning domain (MSD1) of CFTR (Laselva et al., 2016) and enhances the interface between NBD1 and ICL4 (MSD2) (Laselva et al., 2018) The inhibitory effect on Pseudomonas aeruginosa-dependent IL-8 transcription at nanomolar concentrations in CF-derived bronchial epithelial cells (Tamanini et al., 2011) is another interesting property of TMA. This evidence concerns the gene CXCL8 and cystic fibrosis.