Previous studies have revealed that CD164 was involved in tumor progression via the regulation of cell proliferation and apoptosis in several cancers.13, 14, 15, 23, 32 In addition, CD164 was implicated in regulating the migration and invasion of lung cancer and medulloblastoma cells.17, 18 In vivo, knocking down CD164 could significantly inhibit the tumor growth and metastasis of colon and ovarian cancer in nude mice.23 Similarly, in our study, silencing of CD164 could significantly inhibit the proliferation, migration, and invasion of tumor cells in vitro. This evidence concerns the gene CD164 and cancer.