Strikingly, 8 (22%) of the C9ORF72 interactors during oxidative stress were known stress granule components20–22 including two ALS-linked proteins (hnRNPA2B1 and hnRNPA1, Fig. 1c, Supplementary Table 1). The gene discussed is HNRNPA2B1; the disease is amyotrophic lateral sclerosis.