EZH2 and breast carcinoma: We hypothesized that in the cytoplasm, pEZH2(T367) may regulate the migratory and invasive abilities of breast cancer cells, and set out to rescue the expression of WT-EZH2 and the phospho-deficient T367A-EZH2 mutant in MDA-MB-231, -468, and SUM159 cells with EZH2 3′UTR knockdown (Fig. 4a, Supplementary Fig. 4A).