In the 104 primary invasive carcinomas, high cytoplasmic pEZH2(T367) was significantly associated with higher histological grade (p = 0.028), ER- (p = 0.0003), PR- (p = 0.0002), and triple negative status (p = 0.0006) (Supplementary Table 2). Here, ESR1 is linked to invasive carcinoma.