It was shown that the interaction of FANCM and the FA core complex is important for ID2 recruitment and mono-ubiquitination34, and thus the defect of FANCM-MM1 mutant in CFS protection is likely related to modulating the function of the FA core complex and ID2, which is in line with the previous findings that the FA core proteins and ID2 are important for CFS protection14. The gene discussed is FANCA; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.