Furthermore, CB2 are expressed in the bladder [231] and are involved in the treatment of hemorrhagic cystitis, a common side effect of Cyclophosphamide, an antineoplastic alkylating agent usually metabolized by the liver to ACR, which is accumulated in urine and therefore is considered to be the main responsible for Cyclophosphamide-induced cystitis [232]. The gene discussed is CNR2; the disease is chronic cystitis.