Consistently, it has been shown that PPAR-α stimulation by PEA lowers blood pressure and prevents hypertension-induced renal damage in hypertensive rats by inhibiting the subunit p47phox of NOXs (a key regulatory subunit essential for NOXs functioning) [349], and by significantly reducing the hypertension-induced increased levels of MDA in urine and renal tissues (Figure 5) [348]. This evidence concerns the gene NCF1 and hypertensive disorder.