In the context of cardiovascular diseases is also interesting to mention hypertension, which is characterized by (1) deregulation of ECS with increased activity of FAAH and MAGL, (2) increased levels of AEA, 2-AG, and NADA, and (3) increased expression of CB1 [209], effects that are accompanied by an imbalance of redox homeostasis (decreased activities of glutathione peroxidase (GPx), glutathione reductase (GR) and the antioxidant enzymes Cu2+/Zn2+-superoxide dismutase (SOD) and catalase (CAT)). The gene discussed is CNR1; the disease is Hypertension.