PPARA and early-onset autosomal dominant Alzheimer disease: Such increase in hippocampal PPAR-α expression could trigger the induction of its target genes encoding for peroxisomal membrane protein-70 (PMP70) and ACOX1, which are involved in fatty acyl-CoA transport across peroxisomal membranes and peroxisomal β-oxidation respectively, by evoking a compensatory response to Aβ-mediated mitochondrial insult that occurs in early stage of Alzheimer’s disease [4,5,6,360].