Consistently, the decrease in striatal SOD expression, which resulted in the 6-hydroxydopamine (6-OHDA)-induced Parkinson disease mouse model, was completely counteracted by PPAR-α agonists confirming the ability of this nuclear receptor to regulate the transcription of antioxidant enzymes (Figure 5) [138,346,350]. The gene discussed is PPARA; the disease is Parkinson disease.