SOD1 and Parkinson disease: The abovementioned findings, coupled with a recent report demonstrating that PEA treatment (through binding PPAR-α) is able to induce SOD and dampen ROS/RNS-induced oxidative damage in 6-OHDA-induced mouse model of Parkinson disease, additionally suggest the neuroprotective scavenging effects of this lipid compound (Figure 5) [363].