Terakura et al. demonstrated that BCAA supplementation significantly reduced hepatic steatosis and suppressed inflammatory gene expression in the livers of db/db mice [40], while Zhang et al. found that BCAA supplementation aggravated the markers of liver damage in C57BL/6J mice caused by high-fat diet through mTOR activation [50]. The gene discussed is MTOR; the disease is Hepatic steatosis.