In line with the complex genetic structure of MM, most of the mutations were detected only in single patient samples (e.g., NRAS, ATM, NTRK1, cMET, HER2, BRAF, IDH1, IDH2) (see Figure 1), and most of them were not targetable in MM and other cancers beyond clinical trials. The gene discussed is NRAS; the disease is Miyoshi myopathy.