Branca et al. [46] used a genetic approach to remove the Nrf2 gene from APP/PS1 mice, and found that the lack of Nrf2 significantly exacerbates cognitive deficits in APP/PS1, suggesting a clear link between Nrf2 and AD-mediated cognitive decline and further strengthens the connection between Nrf2 and AD. This evidence concerns the gene APP and Alzheimer disease.