PRNP and prion disease: Furthermore, IEC-restricted Prnp ablation did not affect disease duration (survival times) or susceptibility, as all of the βNF-treated PrnpΔIEC mice also succumbed to clinical prion disease with similar survival times (mean of 306 ± 11 days; median of 306 days; n = 12/12; P = 0.673 by one-way analysis of variance [ANOVA] with Dunnett's posttest) (Table 1).