As an example, for the T1D data, in the IKZF3 gene, a lymphoid transcription factor and T1D candidate gene (Morgan et al. 1997; Hosokawa et al. 1999; Barrett et al. 2009), EA reduces the number of transcripts from 18 to four, and quantitation demonstrates there is a shift in expression such that the isoform IKZF3.iAug10 is expressed more frequently in CD4+ and CD8+ T cells than in CD19+ B cells (Supplementary Figures 5 and 6, Additional File 1). This evidence concerns the gene CD8A and type 1 diabetes mellitus.