The present study expands on previous work by the Sidranski's group (Izumchenko et al, 2014), who showed that ERRFI1 targeting by miR‐200 (a known ERRFI1 targeting miRNA) heightens EGFR signaling and consequently generates a condition of EGFR addiction in lung and pancreas cancer cells expressing wt EGFR. We hypothesize that the dominant role of a given miRNA in ERRFI1 regulation may reflect variables such as tumor cell identity, stage of tumor evolution, and therapeutic setting. The gene discussed is ERRFI1; the disease is neoplasm.