NFKB1 and glomerulosclerosis: TWG alleviates glomerulosclerosis by exerting antimicroinflammatory effects, including reducing macrophage infiltration in the glomeruli, suppressing TNF-α, IL-1β and TGF-β1 overexpression in the kidney and inhibiting p38 MAPK and NF-κB signaling activities [28, 29].