LEP: Leptin, LEPR: Leptin Receptor, FABP2: Fatty Acid Binding Protein 2, FTO: Fat Mass and Obesity associated, GRB14: Growth factor receptor bound protein 14, ST6GAL1: Sialyltransferase 6 galactosidase 1 protein, VPS26A: Vacuolar protein sorting associated protein, HMG20A: High mobility group protein 20 A, AP3S2: Adaptor related protein complex, HNF4A: Hepatocyte nuclear factor 4 A. the Global MAF values are taken from SNPedia, while the p-value indicates the significance of difference between the GMAF and the MAF observed in the current study. This evidence concerns the gene AP3S2 and obesity due to melanocortin 4 receptor deficiency.