Comparison of the proteins found with different levels in AD versus non-AD CSF biomarker profiles and in the models able to classify CSF-defined AD pathology with those associated with CSF Aβ1–42, tau, and P-tau181 in Venn diagrams (Additional file 1: Figures S6 and S7, respectively) revealed mixed overlaps. The gene discussed is MAPT; the disease is Alzheimer disease.