To determine the clinical correlation of miR-133a-3p with EGFR, FGFR1, IGF1R and MET expression, and PI3K/AKT signaling activity in clinical PCa tissues, the miR-133a-3p expression and protein levels of EGFR, FGFR1, IGF1R and MET and pAKT expression were examined in four bone metastatic and four non-bone metastatic PCa tissues. This evidence concerns the gene EGFR and posterior cortical atrophy.