KISS1 and colorectal cancer: This may be related to the use of different biomarkers, different immunohistochemical methods, or even different patients (such as Wang W. et al., who reported that KiSS-1 expression was statistically significantly higher in colorectal cancer tissue than in corresponding adjacent normal mucosa [30], Wu Q. et al. reported that CD44 expression was not associated with LNM in multivariate logistic regression analysis [17], and Yusup A. et al. reported that Twist1 expression was not correlated with survival [31]).