We have, therefore, extended the receptor tyrosine kinase (RTK) and immune checkpoint molecular interdependence phenomenon, previously only observed in EGFR mutated lung cancers (Akbay et al., 2013), to BLBC, where PD-L1 expression is frequently observed and where elevated EGFR expression is associated with poor survival. The gene discussed is NTRK1; the disease is lung carcinoma.