As a whole, 87.7% of RA patients received the same TNF-α antagonist (either Etanercept or Adalimumab) during the 1-year follow-up, 2.4% (N = 57) of those patients switched to another TNF-α antagonist after the baseline period, 7.1% (N = 173) of the study cohort received a second-line biologic agent (Rituximab), while the remaining patients discontinued use of any TNF-α antagonist. This evidence concerns the gene TNF and rheumatoid arthritis.