HLA-C and Sepsis: The expression of major histocompatibility complex (MHC) class II on monocytes is a vital pre requisite for adequate immune function.[20] Several initial studies have shown that HLA-DR expression on monocytes decreases after surgery, major trauma and organ transplantation.[21] Wasmuth et al.[7] in their study assessed the immunological parameters in patients with ACLF, severe sepsis and compensated cirrhosis.