Specifically, interactions between miR-130b-3p/ATXN2, and miR-142-5p/NAMPT (Table 4) may play important roles in regulation of host metabolism, given that loss of function mutations in both ATXN2 and NAMPT are associated with obesity and diabetes mellitus [33, 34]. The gene discussed is ATXN2; the disease is obesity due to melanocortin 4 receptor deficiency.