In their experience, >80% of SCAs lacked galectin-3 expression, and galectin-3 was uniformly present in hormonally active adenomas, including a case of Crooke cell adenoma, a rare and reportedly aggressive variant of corticotroph adenoma showing Crooke hyaline changes in >50% of neoplastic cells. The gene discussed is LGALS3; the disease is ACTH-producing pituitary gland adenoma.