Deregulation of mTOR signaling has been identified as a phenotypic feature common to various forms of ASD, including fragile X syndrome, and mutations in tuberous sclerosis complex 1 and 2 (TSC1/2), neurofibromatosis 1, and phosphatase and tensin homolog (PTEN) (Huber et al., 2015). Here, PTEN is linked to fragile X syndrome.