NFKB1 and heart failure: Overexpression of miR‐181c could decrease mt‐COX1 protein expression, increasing production of reactive oxygen species in heart failure.31 Mir‐148 was a repressor of NF‐kB signalling, playing roles in cardiac injury.32 In addition, miR‐19 was demonstrated to involve in cardiac remodelling by controlling cardiac fibroblast proliferation and migration.33 Moreover, in “loss” module, a number of heart failure‐related miRNAs were also extracted.