Recent studies suggest that adipose derived stem cells (ADSCs) show beneficial effects to improve liver fibrosis.4 In addition, fibroblast growth factor (FGF) 21 improves lipid profiles and hepatic steatosis.5 To enhance the therapeutic effects of ADSCs on liver fibrosis, we established FGF21‐secreting ADSCs (FGF21_ADSCs) and investigated their effects on thioacetamide (TAA)‐induced liver fibrosis in mice. The gene discussed is FGF21; the disease is Hepatic steatosis.