Syndecan-2 and tenascin, profibrotic genes that are increased in lung tissues of patients with systemic sclerosis or IPF, are induced in fibroblasts by TGF-β in an IGFBP-3-dependent manner or by IGFBP-3 alone [120, 121]. This evidence concerns the gene IGFBP3 and idiopathic pulmonary fibrosis.