This is consistent with the results of the study by Bardin et al. which suggested that the protective role of ERβ was based on direct (ERβ-specific) effects limiting cell proliferation [49], and also the studies of Jarred et al., which suggested that activating ERβ reduced proliferation in vitro in cell lines and also reduced the development of PCa in animal models [50]. The gene discussed is ESR2; the disease is posterior cortical atrophy.