Based on the function and interaction of lncRNA-related proteins, here we propose a hypothetical model for the role of lncRNAs in pathogenesis of RA, SLE and SS, with a focus in TMEVPG1, MALAT1, GAS5, NEAT1, Lnc-DC, and C5T1 (Figure 3). This evidence concerns the gene IFNG-AS1 and synovial sarcoma.