UPIA patients who differentiated into definite arthritis, had significantly higher baseline IL-6 PB levels (9.27 ± 2.36 pg/ml) compared to patients who remained as UPIA (3.49 ± 4.90 pg/ml; p = 0.01), whereas comparable PB VEGF-A and VEGF-D levels were found comparing the two subgroups (Table 1). The gene discussed is IL6; the disease is Arthritis.