FOXI3 and Familial prostate cancer: This marks the first signs of metastatic potential of FOXI3. Indeed, given the bounty of research demonstrating EMT as critical to the invasive potential of prostate cancer, future research examining whether FOXI3 expression functions in EMT, invasion, and metastasis could bring together these clinical associations to key processes of tumor progression controlled by FOXI3. Within the TCGA breast cancer cohort (Cancer Genome Atlas Research Network, 2012), some of the primary tumors were annotated for the site where distant metastasis was observed.