They also demonstrated that tumors from Villin-Lin28b/let-7IEC-KO mice exhibited a significant upregulation of stem cell markers including Bmi1, Lrig1, Olfm4, ASCL2, Prom1, LGR5, Msi1, and SOX9, suggesting an expansion of CRC and +4 stem cell-like compartments. This evidence concerns the gene LGR5 and colorectal carcinoma.