Among NSCLC patients, those with BM have an increased frequency of EGFR mutations than those without brain metastasis and conversely, among EGFR mutant NSCLC patients the incidence of BM (70%) greatly surpasses the incidence of BM in wild-type (wt) EGFR NSCLC patients (38%) (17). Here, EGFR is linked to non-small cell lung carcinoma.