EGFR and lung carcinoma: Following this, a phase 1 study in 34 patients with EGFR mutant lung cancer treated with escalating pulse doses of erlotinib found the maximum tolerated dose to be 1,200 mg given on days 1 and 2, with 50 mg given on days 3–7 weekly and it should be noted that 32% of patients had BM at study entry and none of these patients had progression of an untreated CNS metastasis or new CNS lesions while on study (37).