The drug reduces EGFR autophosphorylation in intact tumor cells at a median inhibitory concentration of 20 nM although this ranges from 5 (nM) and 6 (nM) in exon 19 deletion and L858R cell models respectively to >2,000 (nM) in T790M models (29, 30). The gene discussed is EGFR; the disease is neoplasm.