EGFR and non-small cell lung carcinoma: The BRAIN study was a multicenter, open-label, parallel randomized controlled trial of 176 Asian EGFR mutant NSCLC patients with at least three brain lesions; patients treated with icotinib had a median intracranial PFS of 10.0 months compared to 4.8 months in those treated with whole brain irradiation plus concurrent or sequential chemotherapy, translating to a 44% risk reduction from intracranial progression or death, and making this a potentially promising option (52).