In this regard, 5′-end CpG island methylation of TUSC3, ATRNL1, POMT1 and SAMD4A was frequently observed in Colon Adenocarcinoma (COAD), Rectum Adenocarcinoma (READ), Stomach Adenocarcinoma (STAD), Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC), Esophageal Carcinoma (ESCA), and Head-Neck Squamous Cell Carcinoma (HNSC). The gene discussed is TUSC3; the disease is head and neck squamous cell carcinoma.