The coding genes affected by this epigenetic lesion cover all the molecular pathways related to cancer biology, such as DNA repair (BRCA1, MHL1 and MGMT), cell cycle (p16INK4a and p15INK4b), apoptosis (DAPK and TMS1) or cell adherence (E-cadherin and cadherin-11) [34]. This evidence concerns the gene CDKN2A and cancer.