Data mining of a collection of 1,001 human cancer cell lines from the Sanger Institute, studied by the same DNA methylation microarray platform herein used, [33] confirmed the existence of hypermethylation of TUSC3, ATRNL1, POMT1 or SAMD4A in a significant proportion of these transformed cells across different tumor types (Figure 4A). The gene discussed is SAMD4A; the disease is cancer.