For the other three newly identified hypermethylated genes, POMT1 is involved in protein glycosylation (as also described above for TUSC3) and has been found to be related to the development of hematological malignancies [38], a tumor type also enriched in our cell line and TCGA methylation screening; ATRNL1 regulates energy homoeostasis and has been found inserted in the EML4-ALK fusion gene [39]; and SAMD4A is an RNA-binding protein linked to drug resistance in cancer cells [40]. The gene discussed is TUSC3; the disease is cancer.