BET protein BRD4 regulates transcription of key genes for cell cycle progression, such as the MYC oncogene that is often amplified in CTCL, by recruiting the positive transcription elongation factor and phosphorylating the C terminal domain serine 2 on RNA polymerase II [25, 28, 29]. The gene discussed is MYC; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.