ESR1 and neoplasm: We also found this 9 RNA classifer to have significant prognostic value for both ER+ (HR = 1.75 (CI: 1.44 – 2.13), p = 2.15E-08) and ER- tumours (HR = 2.04 (CI: 1.33 – 3.12), p = 0.001) in the Breast Cancer Meta-base: 10 cohorts 22K gene data on 1888 samples from the SurvExpress database [28].