In the MDA-MB-453 cells, expression of genes that were positively correlated with TP63 expression in ER- wtTP53 tumours (IL6ST, IRF2, GBP2, JAK2, IL13RA1, CXCR6 – above the horizontal dotted line in Figure 5A) were reduced post TP63 knockdown (left side of the vertical dotted line in Figure 5A, p <0.05, student’s t-test), STAT6 did not change, and PIK3R3 did not follow the predicted trend. This evidence concerns the gene IRF2 and neoplasm.