In the T47D cells, expression of genes that were positively correlated with Δ133TP53 expression in ER+ mTP53 tumours, 5/8 genes (IL6ST, CXCR6, GBP2, IRF2 and JAK2) were reduced post Δ133TP53 knockdown (Figure 5D), whilst STAT6 and PIK3R3 that were negatively correlated with Δ133TP53 expression in ER+ mTP53 were increased after Δ133TP53 knockdown (Figure 5D). The gene discussed is GBP2; the disease is neoplasm.